Biogenic Nanomagnetic Carriers Derived from Magnetotactic Bacteria: Magnetic Parameters of Magnetosomes Inside Magnetospirillum spp.

Magnetotactic bacteria and magnetosomes.

How magnetotactic bacteria make magnetosomes

Magnetotactic bacteria contain chains of magnetosomes that comprise a permanent magnetic dipole in each cell. In two separate, recent papers, Scheffel et a/. and Komeili et a/. describe the roles of the proteins MamJ and MamK in magnetosome chain formation. Here, we describe the two studies and highlight questions that must be addressed in future investigations of how magnetotactic bacteria con...

Formation of magnetosomes in magnetotactic bacteria.

The ability of magnetotactic bacteria to orient and migrate along geomagnetic field lines is based on intracellular magnetic structures, the magnetosomes, which comprise nano-sized, membrane bound crystals of magnetic iron minerals. The formation of magnetosomes is achieved by a biological mechanism that controls the accumulation of iron and the biomineralization of magnetic crystals with a cha...

Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine

Magnetotactic bacteria belong to a group of bacteria that synthesize iron oxide nanoparticles covered by biological material that are called magnetosomes. These bacteria use the magnetosomes as a compass to navigate in the direction of the earth's magnetic field. This compass helps the bacteria to find the optimum conditions for their growth and survival. Here, we review several medical applica...

Preparation and anti-tumor efficiency evaluation of doxorubicin-loaded bacterial magnetosomes: magnetic nanoparticles as drug carriers isolated from Magnetospirillum gryphiswaldense.

Bacterial magnetosomes (BMs) are commonly used as vehicles for certain enzymes, nucleic acids and antibodies, although they have never been considered drug carriers. To evaluate the clinical potential of BMs extracted from Magnetospirillum gryphiswaldense in cancer therapy, doxorubicin (DOX) was loaded onto the purified BMs at a ratio of 0.87 +/- 0.08 mg/mg using glutaraldehyde. The DOX-coupled...